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INASP is continually exploring options for further work and new projects. As part of these exploratory measures, several in-depth country profiles have been commissioned to bring insight into research and knowledge systems in various countries. In this document, we look at South Sudan; the country’s background, the research landscape, higher education system and extent of use of research in policy making. We also include a section on political analysis by Jason Mosley. In the interests of openness and sharing, INASP makes these reports available online for use by peer organizations and other interested parties. Views are the authors’ own.